منابع مشابه
Apolipoprotein L1, income and early kidney damage
BACKGROUND The degree to which genetic or environmental factors are associated with early kidney damage among African Americans (AAs) is unknown. METHODS Among 462 AAs in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, we examined the cross-sectional association between apolipoprotein L1 (APOL1) risk variants and income with: 1) mildly reduced eGFR (<75 mL...
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The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps related to renal blood flow, which appears to lim...
متن کاملThe innate immune factor apolipoprotein L1 restricts HIV-1 infection.
Apolipoprotein L1 (APOL1) is a major component of the human innate immune response against African trypanosomes. Although the mechanism of the trypanolytic activity of circulating APOL1 has been recently clarified, the intracellular function(s) of APOL1 in human cells remains poorly defined. Like that of many genes linked to host immunity, APOL1 expression is induced by proinflammatory cytokine...
متن کاملPlasma apolipoprotein L1 levels do not correlate with CKD.
Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is unclear. We examined associations of plasma APOL1 levels with plasma cytokine levels, dyslipidemia, and APOL1 genotype in a nested case-contr...
متن کاملApolipoprotein L1-associated nephropathy and the future of renal diagnostics.
Apolipoprotein L1 (APOL1)-associated nephropathies comprise a spectrum of related nondiabetic kidney diseases strongly associated with theG1 andG2 coding risk variants in populations with recent African ancestry.1 The spectrum is extremely heterogeneous, ranging from nephrotic syndrome with collapsing glomerulopathy in patients with HIV-associated nephropathy2 to slowly progressive renal failur...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2018
ISSN: 1062-4821
DOI: 10.1097/mnh.0000000000000399